Sexual dimorphism in skin immunity is mediated by an androgen-ILC2-dendritic cell axis.
Science
; 384(6692): eadk6200, 2024 Apr 12.
Article
em En
| MEDLINE
| ID: mdl-38574174
ABSTRACT
Males and females exhibit profound differences in immune responses and disease susceptibility. However, the factors responsible for sex differences in tissue immunity remain poorly understood. Here, we uncovered a dominant role for type 2 innate lymphoid cells (ILC2s) in shaping sexual immune dimorphism within the skin. Mechanistically, negative regulation of ILC2s by androgens leads to a reduction in dendritic cell accumulation and activation in males, along with reduced tissue immunity. Collectively, our results reveal a role for the androgen-ILC2-dendritic cell axis in controlling sexual immune dimorphism. Moreover, this work proposes that tissue immune set points are defined by the dual action of sex hormones and the microbiota, with sex hormones controlling the strength of local immunity and microbiota calibrating its tone.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Células Dendríticas
/
Linfócitos
/
Caracteres Sexuais
/
Imunidade Inata
/
Androgênios
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos