Metabolites and Cognitive Decline in a Puerto Rican Cohort.
J Alzheimers Dis
; 99(s2): S345-S353, 2024.
Article
em En
| MEDLINE
| ID: mdl-38578885
ABSTRACT
Background:
Recent studies have identified plasma metabolites associated with cognitive decline and Alzheimer's disease; however, little research on this topic has been conducted in Latinos, especially Puerto Ricans.Objective:
This study aims to add to the growing body of metabolomics research in Latinos to better understand and improve the health of this population.Methods:
We assessed the association between plasma metabolites and global cognition over 12 years of follow-up in 736 participants of the Boston Puerto Rican Health Study (BPRHS). Metabolites were measured with untargeted metabolomic profiling (Metabolon, Inc) at baseline. We used covariable adjusted linear mixed models (LMM) with a metaboliteâ*âtime interaction term to identify metabolites (of 621 measured) associated with â¼12 years cognitive trajectory.Results:
We observed strong inverse associations between medium-chain fatty acids, caproic acid, and the dicarboxylic acids, azelaic and sebacic acid, and global cognition. N-formylphenylalanine, a tyrosine pathway metabolite, was associated with improvement in cognitive trajectory.Conclusions:
The metabolites identified in this study are generally consistent with prior literature and highlight a role medium chain fatty acid and tyrosine metabolism in cognitive decline.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hispânico ou Latino
/
Metabolômica
/
Disfunção Cognitiva
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Caribe
/
Puerto rico
Idioma:
En
Revista:
J Alzheimers Dis
Assunto da revista:
GERIATRIA
/
NEUROLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos