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Vaccine-Elicited Antibodies Restrict Glucose Availability to Control Brucella Infection.
Ponzilacqua-Silva, Bárbara; Dadelahi, Alexis S; Abushahba, Mostafa F N; Moley, Charles R; Skyberg, Jerod A.
Afiliação
  • Ponzilacqua-Silva B; Department of Veterinary Pathobiology, College of Veterinary Medicine.
  • Dadelahi AS; Laboratory for Infectious Disease Research, University of Missouri, Columbia.
  • Abushahba MFN; Department of Veterinary Pathobiology, College of Veterinary Medicine.
  • Moley CR; Laboratory for Infectious Disease Research, University of Missouri, Columbia.
  • Skyberg JA; Department of Veterinary Pathobiology, College of Veterinary Medicine.
J Infect Dis ; 230(4): e818-e823, 2024 Oct 16.
Article em En | MEDLINE | ID: mdl-38586904
ABSTRACT
The impact of vaccine-induced immune responses on host metabolite availability has not been well studied. Here we show that prior vaccination alters the metabolic profile of mice challenged with Brucella melitensis. In particular, glucose levels were reduced in vaccinated mice in an antibody-dependent manner. We also found the glucose transporter gene gluP plays a lesser role in B melitensis virulence in vaccinated wild type mice relative to vaccinated mice unable to secrete antibodies. These data indicate that vaccine-elicited antibodies protect the host in part by restricting glucose availability. Moreover, Brucella and other pathogens may need to employ different metabolic strategies in vaccinated hosts.
Assuntos
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Brucelose / Vacina contra Brucelose / Brucella melitensis / Glucose / Anticorpos Antibacterianos Limite: Animals Idioma: En Revista: J Infect Dis Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Brucelose / Vacina contra Brucelose / Brucella melitensis / Glucose / Anticorpos Antibacterianos Limite: Animals Idioma: En Revista: J Infect Dis Ano de publicação: 2024 Tipo de documento: Article