[Application and optimization of CRISPRi to the biology of Mycobacterium tuberculosis].
Zhonghua Jie He He Hu Xi Za Zhi
; 47(4): 376-382, 2024 Apr 12.
Article
em Zh
| MEDLINE
| ID: mdl-38599816
ABSTRACT
Tuberculosis, caused by infection with Mycobacterium tuberculosis (MTB), remains a global public health challenge. Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) strains make tuberculosis more difficult to control. New tools to study the biology of MTB can identify novel targets for drug discovery. Recently, the Clustered Regularly Interspaced Short Palindromic Repeats interference (CRISPRi) combined with next-generation sequencing has provided many novel insights into the physiology and genetics of MTB. This review summarizes the application and optimization of CRISPRi in MTB biology.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tuberculose Resistente a Múltiplos Medicamentos
/
Tuberculose Extensivamente Resistente a Medicamentos
/
Mycobacterium tuberculosis
Limite:
Humans
Idioma:
Zh
Revista:
Zhonghua Jie He He Hu Xi Za Zhi
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China