[The correlation between sperm DNA damage and IVF-ET clinical pregnancy outcomes in different BMI population with normal routine semen examination].
Zhonghua Nan Ke Xue
; 29(6): 490-197, 2023 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-38602720
ABSTRACT
OBJECTIVE:
To analyze the correlation between sperm DFI, HDS and IVF-ET pregnancy outcomes in different BMI populations with normal routine semen examination.METHODS:
The clinical data of 199 cycles of IVF-ET were retrospectively analyzed. Sperm chromatin structure analysis based on flow cytometry was used to detect sperm DFI and HDS. The correlation between sperm DFI, HDS and pregnancy outcome of IVF-ET were analyzed.RESULTS:
The sperm DFI was negatively correlated with IVF-ET pregnancy in overweight (24.0 kg/m2≤BMI<28.0 kg/m2) population (OR=0.935, P=0.043). In the normal BMI group (18.5 kg/m2≤BMI < 24.0 kg/m2), the clinical pregnancy outcome of IVF-ET was not significantly correlated with sperm DFI, and was negatively correlated with male age (OR=0.744, P=0.020). In the obese population (BMI ≥ 28.0 kg/m2) , there was no significant correlation between the clinical pregnancy outcome of IVF-ET and sperm DNA fragmentation index (DFI) , but a negative correlation with male BMI (OR = 0.779, P = 0.043).CONCLUSION:
The male BMI affected the correlation between sperm DFI and IVF-ET pregnancyoutcomes:
â Sperm DFI was only associated with IVF-ET clinical pregnancy outcome in the overweight population; â¡ In normal BMI and obese populations, male age and male BMI were important factors affecting IVF-ET clinical pregnancy outcome respectively; â¢No correlation was found between sperm HDS and IVF-ET pregnancy outcomes.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Resultado da Gravidez
/
Sobrepeso
Limite:
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
Zh
Revista:
Zhonghua Nan Ke Xue
Assunto da revista:
MEDICINA REPRODUTIVA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China