Two inhibitory neuronal classes govern acquisition and recall of spinal sensorimotor adaptation.
Science
; 384(6692): 194-201, 2024 Apr 12.
Article
em En
| MEDLINE
| ID: mdl-38603479
ABSTRACT
Spinal circuits are central to movement adaptation, yet the mechanisms within the spinal cord responsible for acquiring and retaining behavior upon experience remain unclear. Using a simple conditioning paradigm, we found that dorsal inhibitory neurons are indispensable for adapting protective limb-withdrawal behavior by regulating the transmission of a specific set of somatosensory information to enhance the saliency of conditioning cues associated with limb position. By contrast, maintaining previously acquired motor adaptation required the ventral inhibitory Renshaw cells. Manipulating Renshaw cells does not affect the adaptation itself but flexibly alters the expression of adaptive behavior. These findings identify a circuit basis involving two distinct populations of spinal inhibitory neurons, which enables lasting sensorimotor adaptation independently from the brain.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Rememoração Mental
/
Medula Espinal
/
Células de Renshaw
/
Neurônios Motores
/
Inibição Neural
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Bélgica