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A plant NLR receptor employs ABA central regulator PP2C-SnRK2 to activate antiviral immunity.
Huang, Shen; Wang, Chunli; Ding, Zixuan; Zhao, Yaqian; Dai, Jing; Li, Jia; Huang, Haining; Wang, Tongkai; Zhu, Min; Feng, Mingfeng; Ji, Yinghua; Zhang, Zhongkai; Tao, Xiaorong.
Afiliação
  • Huang S; The Key Laboratory of Plant Immunity, Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, P. R. China.
  • Wang C; The Key Laboratory of Plant Immunity, Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, P. R. China.
  • Ding Z; The Key Laboratory of Plant Immunity, Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, P. R. China.
  • Zhao Y; The Key Laboratory of Plant Immunity, Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, P. R. China.
  • Dai J; The Key Laboratory of Plant Immunity, Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, P. R. China.
  • Li J; The Key Laboratory of Plant Immunity, Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, P. R. China.
  • Huang H; The Key Laboratory of Plant Immunity, Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, P. R. China.
  • Wang T; The Key Laboratory of Plant Immunity, Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, P. R. China.
  • Zhu M; The Key Laboratory of Plant Immunity, Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, P. R. China.
  • Feng M; The Key Laboratory of Plant Immunity, Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, P. R. China.
  • Ji Y; Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China.
  • Zhang Z; Yunnan Academy of Tobacco Agricultural Sciences, Key Laboratory of Tobacco Biotechnological Breeding, National Tobacco Genetic Engineering Research Center, Kunming, 650021, China.
  • Tao X; The Key Laboratory of Plant Immunity, Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, P. R. China. taoxiaorong@njau.edu.cn.
Nat Commun ; 15(1): 3205, 2024 Apr 13.
Article em En | MEDLINE | ID: mdl-38615015
ABSTRACT
Defence against pathogens relies on intracellular nucleotide-binding, leucine-rich repeat immune receptors (NLRs) in plants. Hormone signaling including abscisic acid (ABA) pathways are activated by NLRs and play pivotal roles in defence against different pathogens. However, little is known about how hormone signaling pathways are activated by plant immune receptors. Here, we report that a plant NLR Sw-5b mimics the behavior of the ABA receptor and directly employs the ABA central regulator PP2C-SnRK2 complex to activate an ABA-dependent defence against viral pathogens. PP2C4 interacts with and constitutively inhibits SnRK2.3/2.4. Behaving in a similar manner as the ABA receptor, pathogen effector ligand recognition triggers the conformational change of Sw-5b NLR that enables binding to PP2C4 via the NB domain. This receptor-PP2C4 binding interferes with the interaction between PP2C4 and SnRK2.3/2.4, thereby releasing SnRK2.3/2.4 from PP2C4 inhibition to activate an ABA-specific antiviral immunity. These findings provide important insights into the activation of hormone signaling pathways by plant immune receptors.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Ácido Abscísico Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Ácido Abscísico Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2024 Tipo de documento: Article