Developmental priming of early cerebrovascular ageing: Implications across a lifetime.
Int J Geriatr Psychiatry
; 39(4): e6090, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38629845
ABSTRACT
INTRODUCTION:
Neurological conditions such as Alzheimer's disease and stroke represent a substantial health burden to the world's ageing population. Cerebrovascular dysfunction is a key contributor to these conditions, affecting an individual's risk profile, age of onset, and severity of neurological disease. Recent data shows that early-life events, such as maternal health during pregnancy, birth weight and exposure to environmental toxins can 'prime' the vascular system for later changes. With age, blood vessels can become less flexible and more prone to damage. This can lead to reduced blood flow to the brain, which is associated with cognitive decline and an increased risk of stroke and other cerebrovascular diseases. These in turn increase the risk of vascular dementia and Alzheimer's disease.OBJECTIVES:
We aim to explore how early life factors influence cerebrovascular health, ageing and disease.METHODS:
We have reviewed recently published literature from epidemiological studies, clinical cases and basic research which explore mechanisms that contribute to cerebrovascular and blood-brain barrier dysfunction, with a particularly focus on those that assess contribution of early-life events or vascular priming to subsequent injury.RESULTS:
Perinatal events have been linked to acute cerebrovascular dysfunction and long-term structural reorganisation. Systemic disease throughout the lifetime that produce inflammatory or oxidative stress may further sensitise the cerebrovasculature to disease and contribute to neurodegeneration.CONCLUSIONS:
By identifying these early-life determinants and understanding their mechanisms, scientists aim to develop strategies for preventing or mitigating cerebrovascular ageing-related issues.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Demência Vascular
/
Transtornos Cerebrovasculares
/
Acidente Vascular Cerebral
/
Doença de Alzheimer
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Int J Geriatr Psychiatry
Assunto da revista:
GERIATRIA
/
PSIQUIATRIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Reino Unido