Your browser doesn't support javascript.
loading
Improvement of immune dysregulation in individuals with long COVID at 24-months following SARS-CoV-2 infection.
Phetsouphanh, Chansavath; Jacka, Brendan; Ballouz, Sara; Jackson, Katherine J L; Wilson, Daniel B; Manandhar, Bikash; Klemm, Vera; Tan, Hyon-Xhi; Wheatley, Adam; Aggarwal, Anupriya; Akerman, Anouschka; Milogiannakis, Vanessa; Starr, Mitchell; Cunningham, Phillip; Turville, Stuart G; Kent, Stephen J; Byrne, Anthony; Brew, Bruce J; Darley, David R; Dore, Gregory J; Kelleher, Anthony D; Matthews, Gail V.
Afiliação
  • Phetsouphanh C; The Kirby Institute, University of New South Wales, Sydney, NSW, Australia. cphetsouphanh@kirby.unsw.edu.au.
  • Jacka B; The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
  • Ballouz S; Garvan Institute for Medical research, Sydney, NSW, Australia.
  • Jackson KJL; School of Computer Science and Engineering, Faculty of Engineering, University of New South Wales, Sydney, NSW, Australia.
  • Wilson DB; Garvan Institute for Medical research, Sydney, NSW, Australia.
  • Manandhar B; The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
  • Klemm V; The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
  • Tan HX; The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
  • Wheatley A; Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Victoria, VIC, Australia.
  • Aggarwal A; Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Victoria, VIC, Australia.
  • Akerman A; The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
  • Milogiannakis V; The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
  • Starr M; The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
  • Cunningham P; NSW State Reference Laboratory for HIV, St. Vincent's Centre for Applied Medical Research, Sydney, NSW, Australia.
  • Turville SG; NSW State Reference Laboratory for HIV, St. Vincent's Centre for Applied Medical Research, Sydney, NSW, Australia.
  • Kent SJ; The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
  • Byrne A; Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Victoria, VIC, Australia.
  • Brew BJ; Heart Lung Clinic, St. Vincent's Hospital Sydney and Faculty of Medicine and Health (UNSW), Sydney, NSW, Australia.
  • Darley DR; Peter Duncan Neurosciences Unit- St Vincent's Centre for Applied Medical Research, Sydney, NSW, Australia.
  • Dore GJ; St. Vincent's Hospital, Darlinghurst, NSW, Australia.
  • Kelleher AD; The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
  • Matthews GV; St. Vincent's Hospital, Darlinghurst, NSW, Australia.
Nat Commun ; 15(1): 3315, 2024 Apr 17.
Article em En | MEDLINE | ID: mdl-38632311
ABSTRACT
This study investigates the humoral and cellular immune responses and health-related quality of life measures in individuals with mild to moderate long COVID (LC) compared to age and gender matched recovered COVID-19 controls (MC) over 24 months. LC participants show elevated nucleocapsid IgG levels at 3 months, and higher neutralizing capacity up to 8 months post-infection. Increased spike-specific and nucleocapsid-specific CD4+ T cells, PD-1, and TIM-3 expression on CD4+ and CD8+ T cells were observed at 3 and 8 months, but these differences do not persist at 24 months. Some LC participants had detectable IFN-γ and IFN-ß, that was attributed to reinfection and antigen re-exposure. Single-cell RNA sequencing at the 24 month timepoint shows similar immune cell proportions and reconstitution of naïve T and B cell subsets in LC and MC. No significant differences in exhaustion scores or antigen-specific T cell clones are observed. These findings suggest resolution of immune activation in LC and return to comparable immune responses between LC and MC over time. Improvement in self-reported health-related quality of life at 24 months was also evident in the majority of LC (62%). PTX3, CRP levels and platelet count are associated with improvements in health-related quality of life.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 / Síndrome de COVID-19 Pós-Aguda Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 / Síndrome de COVID-19 Pós-Aguda Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Austrália