Maternal factor Trim75 contributes to zygotic genome activation program in mouse early embryos.
Mol Biol Rep
; 51(1): 560, 2024 Apr 20.
Article
em En
| MEDLINE
| ID: mdl-38643284
ABSTRACT
BACKGROUND:
Zygotic genome activation (ZGA) is an important event in the early embryo development, and human embryo developmental arrest has been highly correlated with ZGA failure in clinical studies. Although a few studies have linked maternal factors to mammalian ZGA, more studies are needed to fully elucidate the maternal factors that are involved in ZGA. METHODS ANDRESULTS:
In this study, we utilized published single-cell RNA sequencing data from a Dux-mediated mouse embryonic stem cell to induce a 2-cell-like transition state and selected potential drivers for the transition according to an RNA velocity analysis.CONCLUSIONS:
An overlap of potential candidate markers of 2-cell-like-cells identified in this research with markers generated by various data sets suggests that Trim75 is a potential driver of minor ZGA and may recruit EP300 and establish H3K27ac in the gene body of minor ZGA genes, thereby contributing to mammalian preimplantation embryo development.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Zigoto
/
Regulação da Expressão Gênica no Desenvolvimento
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Biol Rep
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China