Biomarkers of NRF2 signalling: Current status and future challenges.
Redox Biol
; 72: 103134, 2024 06.
Article
em En
| MEDLINE
| ID: mdl-38643749
ABSTRACT
The cytoprotective transcription factor NRF2 regulates the expression of several hundred genes in mammalian cells and is a promising therapeutic target in a number of diseases associated with oxidative stress and inflammation. Hence, an ability to monitor basal and inducible NRF2 signalling is vital for mechanistic understanding in translational studies. Due to some caveats related to the direct measurement of NRF2 levels, the modulation of NRF2 activity is typically determined by measuring changes in the expression of one or more of its target genes and/or the associated protein products. However, there is a lack of consensus regarding the most relevant set of these genes/proteins that best represents NRF2 activity across cell types and species. We present the findings of a comprehensive literature search that according to stringent criteria identifies GCLC, GCLM, HMOX1, NQO1, SRXN1 and TXNRD1 as a robust panel of markers that are directly regulated by NRF2 in multiple cell and tissue types. We assess the relevance of these markers in clinically accessible biofluids and highlight future challenges in the development and use of NRF2 biomarkers in humans.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
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Transdução de Sinais
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Estresse Oxidativo
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Fator 2 Relacionado a NF-E2
Limite:
Animals
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Humans
Idioma:
En
Revista:
Redox Biol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Áustria