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LncRNA in periodontal tissue-derived cells on osteogenic differentiation in the periodontitis field.
Du, Yuanhang; Guan, Xiaoyan; Zhu, Yinci; Jin, Suhan; Liu, Jianguo.
Afiliação
  • Du Y; School of Stomatology, Zunyi Medical University, Zunyi, China.
  • Guan X; Department of Orthodontics, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China.
  • Zhu Y; School of Stomatology, Zunyi Medical University, Zunyi, China.
  • Jin S; Department of Orthodontics, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China.
  • Liu J; School of Stomatology, Zunyi Medical University, Zunyi, China.
Oral Dis ; 30(7): 4087-4097, 2024 10.
Article em En | MEDLINE | ID: mdl-38655682
ABSTRACT

OBJECTIVE:

Periodontitis can lead to the destruction of periodontal tissues and potentially tooth loss. Numerous periodontal tissue-derived cells display osteogenic differentiation potential. The presence of differentially expressed long non-coding RNAs (lncRNAs) in these cells indicate their ability to regulate the process of osteogenic differentiation. We aim to elucidate the various lncRNA-mediated regulatory mechanisms in the osteogenic differentiation of periodontal tissue-derived cells in the field of periodontitis at epigenetic modification, transcriptional, and post-transcriptional levels. SUBJECTS AND

METHODS:

We systematically searched the PubMed, Web of Science, and ScienceDirect databases to identify relevant literature in the field of periodontitis discussing the role of lncRNAs in regulating osteogenic differentiation of periodontal tissue-derived cells. The identified literature was subsequently summarized for comprehensive review.

RESULTS:

In this review, we have comprehensively summarized the regulatory mechanisms of lncRNAs in the osteogenic differentiation of periodontal tissue-derived cells in the field of periodontitis and discussed how these lncRNAs provide novel perspectives for understanding the pathogenesis and progression of periodontitis.

CONCLUSION:

These results indicate the pivotal role of lncRNAs as regulators in the osteogenic differentiation of periodontal tissue-derived cells, providing a solid basis for future investigations on the role of lncRNAs in the periodontitis field.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteogênese / Periodontite / Diferenciação Celular / RNA Longo não Codificante Limite: Humans Idioma: En Revista: Oral Dis Assunto da revista: ODONTOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteogênese / Periodontite / Diferenciação Celular / RNA Longo não Codificante Limite: Humans Idioma: En Revista: Oral Dis Assunto da revista: ODONTOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China