FGF2 promotes the proliferation of injured granulosa cells in premature ovarian failure via Hippo-YAP signaling pathway.
Mol Cell Endocrinol
; 589: 112248, 2024 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-38663484
ABSTRACT
Young women undergoing anticancer treatment are at risk of premature ovarian failure (POF). Endometrial-derived stem cells (EnSCs) have demonstrated significant therapeutic potential for treating ovarian insufficiency, although the underlying mechanisms remain to be fully understood. This study aims to further investigate the therapeutic effects of EnSCs, particularly through the paracrine action of fibroblast growth factor 2 (FGF2), on POF. The findings show that exogenous FGF2 enhances the survival of ovarian granulosa cells damaged by cisplatin. FGF2 stimulates the proliferation of these damaged cells by suppressing the Hippo signaling pathway and activating YAP expression. In vivo experiments also revealed that FGF2 treatment significantly improves ovarian reserve and endocrine function in mice with POF. These results suggest that FGF2 can boost the proliferative capacity of damaged ovarian granulosa cells through the Hippo-YAP signaling pathway, providing a theoretical foundation for using EnSCs and FGF2 in clinical treatments for POF.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Fator 2 de Crescimento de Fibroblastos
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Insuficiência Ovariana Primária
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Proliferação de Células
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Via de Sinalização Hippo
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Proteínas de Sinalização YAP
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Células da Granulosa
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Mol Cell Endocrinol
Ano de publicação:
2024
Tipo de documento:
Article