Synthesis of C3-epi-virenose and anomerically activated derivatives.
Tetrahedron Lett
; 140: 155041, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38665383
ABSTRACT
A 9-step synthetic route to a protected form of the C3-epimer of virenose from D-fucose is described. C3-epi-virenose is the carbohydrate unit of the bioactive polyketide elsamicin B and part of the carbohydrate unit of elsamicin A. The developed route enabled preparation of anomerically activated forms of this unique C6-deoxy sugar, including derivatives with 1-acetyl, 1-acetylthio, 1-trichloroacetimidate, 1-bromo, and 1-fluoro substituents.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Tetrahedron Lett
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Áustria