Spitz tumour with ALK rearrangement: A case report and literature review.
Malays J Pathol
; 46(1): 103-108, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38682850
ABSTRACT
Spitz tumour with ALK rearrangement is a recently described entity and a rare tumour. The incidence of Spitz tumour was estimated at 3.63 per 100,000 persons in American paediatric population; while there is no data in Asian population. Here we reported a case of an eleven-year-old Asian boy who presented with a left shin nodule of two months' duration. The skin biopsy revealed a Spitz tumour with predominantly spindle cell morphology arranged in fascicles, vertically orientated nests and radial growth pattern. Junctional component, melanin pigment or Kamino bodies were not identified. Immunohistochemical study displayed homogenous cytoplasmic staining for ALK. Fluorescence in-situ hybridisation (FISH) analysis confirmed ALK rearrangement. Review of the literatures demonstrated that positive ALK immunohistochemistry may not correlate with ALK rearrangement. ALK-rearranged Spitz tumour confirmed with FISH analysis favour clinically benign behaviour despite atypical histomorphology or positive sentinel lymph node. Therefore, correlation of histomorphology, immunohistochemical stain and molecular study are important for the definitive diagnosis of this entity.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Rearranjo Gênico
/
Nevo de Células Epitelioides e Fusiformes
/
Quinase do Linfoma Anaplásico
Limite:
Child
/
Humans
/
Male
Idioma:
En
Revista:
Malays J Pathol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Malásia