Mitochondria and Cancer.
Cold Spring Harb Perspect Med
; 2024 May 01.
Article
em En
| MEDLINE
| ID: mdl-38692736
ABSTRACT
Mitochondria are semiautonomous organelles with diverse metabolic and cellular functions including anabolism and energy production through oxidative phosphorylation. Following the pioneering observations of Otto Warburg nearly a century ago, an immense body of work has examined the role of mitochondria in cancer pathogenesis and progression. Here, we summarize the current state of the field, which has coalesced around the position that functional mitochondria are required for cancer cell proliferation. In this review, we discuss how mitochondria influence tumorigenesis by impacting anabolism, intracellular signaling, and the tumor microenvironment. Consistent with their critical functions in tumor formation, mitochondria have become an attractive target for cancer therapy. We provide a comprehensive update on the numerous therapeutic modalities targeting the mitochondria of cancer cells making their way through clinical trials.
Texto completo:
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Cold Spring Harb Perspect Med
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos