Syndecans and diabetic complications: A narrative review.
Am J Med Sci
; 368(2): 99-111, 2024 08.
Article
em En
| MEDLINE
| ID: mdl-38697476
ABSTRACT
Syndecan (SDC) is a member of the heparan sulfate proteoglycan (HSPG) family. It appears to play a role in the aetiology of diabetic complications, with decreased levels of SDCs being reported in the kidney, retina, and cardiac muscle in models of diabetes mellitus (DM). The reduced levels of SDCs may play an important role in the development of albuminuria in DM. Some studies have provided the evidence supporting the mechanisms underlying the role of SDCs in DM. However, SDCs and the molecular mechanisms involved are complex and need to be further elucidated. This review focuses on the underlying molecular mechanisms of SDCs that are involved in the development and progression of the complications of DM, which may help in developing new strategies to prevent and treat these complications.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações do Diabetes
/
Sindecanas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Am J Med Sci
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Irã