Potential for targeting small heat shock protein modifications.

Wang, Binyou; Pratt, Matthew R

Wang, Binyou; Pratt, Matthew R.

Afiliação

Wang B; Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA.
Pratt MR; Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: matthew.pratt@usc.edu.

Trends Pharmacol Sci ; 45(7): 583-585, 2024 Jul.

Article em En | MEDLINE | ID: mdl-38704305

ABSTRACT

ABSTRACT

Small heat shock proteins (sHSPs) play key roles in cellular stress and several human diseases. The direct effects of some post-translational modifications (PTMs) on certain sHSPs have been characterized, raising the possibility that small molecules could be used to modulate these modifications and indirectly up- or downregulate sHSP activity.

Assuntos

Proteínas de Choque Térmico Pequenas; Processamento de Proteína Pós-Traducional; Animais; Humanos; Proteínas de Choque Térmico Pequenas/metabolismo; Proteínas de Choque Térmico Pequenas/química

Palavras-chave

O-GlcNAc; glycation; heat shock proteins; phosphorylation; post-translational modifications; protein aggregation

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Processamento de Proteína Pós-Traducional / Proteínas de Choque Térmico Pequenas Limite: Animals / Humans Idioma: En Revista: Trends Pharmacol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google