Declining Antibody Affinity Over Time After Human Vaccination With a Plasmodium falciparum Merozoite Vaccine Candidate.
J Infect Dis
; 230(3): e753-e757, 2024 Sep 23.
Article
em En
| MEDLINE
| ID: mdl-38723177
ABSTRACT
Maintaining high-affinity antibodies after vaccination may be important for long-lasting immunity to malaria, but data on induction and kinetics of affinity is lacking. In a phase 1 malaria vaccine trial, antibody affinity increased following a second vaccination but declined substantially over 12 months, suggesting poor maintenance of high-affinity antibodies. CLINICAL TRIALS REGISTRATION Australian New Zealand Clinical Trials Registry ACTRN12607000552482.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
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Anticorpos Antiprotozoários
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Malária Falciparum
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Vacinas Antimaláricas
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Afinidade de Anticorpos
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
País/Região como assunto:
Oceania
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Suécia