New-onset atrial fibrillation detected by ambulatory ECG monitoring after transcatheter aortic valve implantation.
EuroIntervention
; 20(9): 591-601, 2024 May 10.
Article
em En
| MEDLINE
| ID: mdl-38726722
ABSTRACT
BACKGROUND:
Little is known about the occurrence of subclinical new-onset atrial fibrillation (NOAF) after transcatheter aortic valve implantation (TAVI).AIMS:
We aimed to evaluate the incidence, predictors, and clinical impact of subclinical NOAF after TAVI.METHODS:
This was a multicentre study, including patients with aortic stenosis (AS) and no previous atrial fibrillation undergoing TAVI, with continuous ambulatory electrocardiogram (AECG) monitoring after TAVI.RESULTS:
A total of 700 patients (79±8 years, 49% female, Society of Thoracic Surgeons score 2.9% [1.9-4.0]) undergoing transarterial TAVI were included (85% balloon-expandable valves). AECG was started 1 (0-1) day after TAVI (monitoring time 14id="26797">12id="18749">13id="26798">14 days). NOAF was detected in 49 patients (7%), with a median duration of 185 (43-421) minutes (atrial fibrillation burden of 0.7% [0.3-2.8]). Anticoagulation was started in 25 NOAF patients (51%). No differences were found in baseline or procedural characteristics, except for a higher AS severity in the NOAF group (peak gradient no NOAF 71.9±23.5 mmHg vs NOAF 85.2±23.8 mmHg; p=0.024; mean gradient no NOAF 44.4±14.7 mmHg vs NOAF 53.8±16.8 mmHg; p=0.004). In the multivariable analysis, the baseline mean transaortic gradient was associated with a higher risk of NOAF after TAVI (odds ratio 1.04, 95% confidence interval 1.01-1.06 for each mmHg; p=0.006). There were no differences between groups in all-cause mortality (no NOAF 4.7% vs NOAF 0%; p=0.122), stroke (no NOAF 1.4% vs NOAF 2.0%; p=0.723), or bleeding (no NOAF 1.9% vs NOAF 4.1%; p=0.288) from the 30-day to 1-year follow-up.CONCLUSIONS:
NOAF detected with AECG occurred in 7% of TAVI recipients and was associated with a higher AS severity. NOAF detection determined the start of anticoagulation therapy in about half of the patients, and it was not associated with an increased risk of clinical events at 1-year follow-up.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estenose da Valva Aórtica
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Fibrilação Atrial
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Eletrocardiografia Ambulatorial
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Substituição da Valva Aórtica Transcateter
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
EuroIntervention
Assunto da revista:
ANGIOLOGIA
/
CARDIOLOGIA
/
TERAPEUTICA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Canadá