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Successful allogeneic fecal microbiota transplantation for severe diversion colitis: a case report.
Cheng, Chuan-Li; Wang, Xiao-Jing; Fan, Li-Xin; Lv, Yong-Ling; Xiong, Kai; Jiang, Zhi-Wei; Gan, Tian; Fu, Guang.
Afiliação
  • Cheng CL; Wuhan Puren Hospital, Wuhan, Hubei, China.
  • Wang XJ; Wuhan Puren Hospital, Wuhan, Hubei, China.
  • Fan LX; Wuhan Puren Hospital, Wuhan, Hubei, China.
  • Lv YL; Maintainbiotech. Ltd. (Wuhan), Wuhan, Hubei, China.
  • Xiong K; Maintainbiotech. Ltd. (Wuhan), Wuhan, Hubei, China.
  • Jiang ZW; Maintainbiotech. Ltd. (Wuhan), Wuhan, Hubei, China.
  • Gan T; Wuhan Puren Hospital, Wuhan, Hubei, China.
  • Fu G; Wuhan Puren Hospital, Wuhan, Hubei, China.
J Int Med Res ; 52(5): 3000605241241000, 2024 May.
Article em En | MEDLINE | ID: mdl-38749910
ABSTRACT
Ileostomy diverts the flow of feces, which can result in malnutrition in the distal part of the intestine. The diversity of the gut microbiota consequently decreases, ultimately leading to intestinal dysbiosis and dysfunction. This condition can readily result in diversion colitis (DC). Potential treatment strategies include interventions targeting the gut microbiota. In this case study, we effectively treated a patient with severe DC by ileostomy and allogeneic fecal microbiota transplantation (FMT). A 69-year-old man presented with a perforated malignant tumor in the descending colon and an iliac abscess. He underwent laparoscopic radical sigmoid colon tumor resection and prophylactic ileostomy. Follow-up colonoscopy 3 months postoperatively revealed diffuse intestinal mucosal congestion and edema along with granular inflammatory follicular hyperplasia, leading to a diagnosis of severe DC. After two rounds of allogeneic FMT, both the intestinal mucosal bleeding and edema significantly improved, as did the diversity of the gut microbiota. The positive outcome of allogeneic FMT in this case highlights the potential advantages that this procedure can offer patients with DC. However, few studies have focused on allogeneic FMT, and more in-depth research is needed to gain a better understanding.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ileostomia / Colite / Transplante de Microbiota Fecal / Microbioma Gastrointestinal Limite: Aged / Humans / Male Idioma: En Revista: J Int Med Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ileostomia / Colite / Transplante de Microbiota Fecal / Microbioma Gastrointestinal Limite: Aged / Humans / Male Idioma: En Revista: J Int Med Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China