Poly(3,4-Ethylenedioxythiophene)/Functional Gold Nanoparticle films for Improving the Electrode-Neural Interface.
Adv Healthc Mater
; : e2400836, 2024 May 17.
Article
em En
| MEDLINE
| ID: mdl-38757738
ABSTRACT
Implantable neural electrodes are indispensable tools for recording neuron activity, playing a crucial role in neuroscience research. However, traditional neural electrodes suffer from limited electrochemical performance, compromised biocompatibility, and tentative stability, posing great challenges for reliable long-term studies in free-moving animals. In this study, a novel approach employing a hybrid film composed of poly(3,4-ethylenedioxythiophene)/functional gold nanoparticles (PEDOT/3-MPA-Au) to improve the electrode-neural interface is presented. The deposited PEDOT/3-MPA-Au demonstrates superior cathodal charge storage capacity, reduced electrochemical impedance, and remarkable electrochemical and mechanical stability. Upon implantation into the cortex of mice for a duration of 12 weeks, the modified electrodes exhibit notably decreased levels of glial fibrillary acidic protein and increased neuronal nuclei immunostaining compared to counterparts utilizing poly(3,4-ethylenedioxythiophene)/poly(styrene sulfonate). Additionally, the PEDOT/3-MPA-Au modified electrodes consistently capture high-quality, stable long-term electrophysiological signals in vivo, enabling continuous recording of target neurons for up to 16 weeks. This innovative modification strategy offers a promising solution for fabricating low-impedance, tissue-friendly, and long-term stable neural interfaces, thereby addressing the shortcomings of conventional neural electrodes. These findings mark a significant advancement toward the development of more reliable and efficacious neural interfaces, with broad implications for both research and clinical applications.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Adv Healthc Mater
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China