Acute exposure and biomarkers assessment in rainbow trout exposed to selected pharmaceuticals.
Environ Toxicol Pharmacol
; 108: 104472, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38763437
ABSTRACT
Pharmaceuticals released from municipal effluents discharges pose a risk to aquatic organisms. The toxicity of 5 pharmaceuticals with distinct therapeutic actions were assessed in rainbow trout olanzapine (antipsychotic), erythromycin (antibiotic), mycophenoate (immunosuppression), pinaverium (anti-inflammatory) and trazodone (sedative). Juveniles were exposed to these drugs for 96â¯h at concentrations between 64⯵g/L up to 40â¯mg/L to reach lethality. Survival was determined and a suite of biomarkers was analyzed for drug biotransformation, oxidative stress/damage and metabolic activity at sublethal concentrations. The data revealed the following toxicity olanzapine >trazodone>mycophenolate>pinaveriumâ¼erythromycin based on mortality. The data also revealed that toxicity was associated to mass, pKa and hydrophobicity and the following sublethal effects GST, LPO and DNA strand breaks. Pharmaceuticals with lower molecular weight, physiological pKa, moderate hydrophobicity, low biotransformation and DNA strand breaks were generally more toxic to fish. However, this should be considered as a general guide in identifying toxic pharmaceuticals in non-target organisms.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Poluentes Químicos da Água
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Biomarcadores
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Oncorhynchus mykiss
Limite:
Animals
Idioma:
En
Revista:
Environ Toxicol Pharmacol
Ano de publicação:
2024
Tipo de documento:
Article