Precision nanoscale patterning of TLR ligands for improved cancer immunotherapy.

Tseng, Chung Yi; Murtada, Farshad; Chou, Leo Y T

Tseng, Chung Yi; Murtada, Farshad; Chou, Leo Y T.

Afiliação

Tseng CY; Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.
Murtada F; Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.
Chou LYT; Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada. Electronic address: leo.chou@utoronto.ca.

Cell Rep Methods ; 4(5): 100782, 2024 May 20.

Article em En | MEDLINE | ID: mdl-38772343

ABSTRACT

ABSTRACT

In a recent issue of Nature Nanotechnology, Zeng et al. report that arraying immuno-stimulatory CpG molecules with specific nanoscale spacing on DNA origami nanoparticles enhanced Th1-polarized immune responses. These results highlight spatial presentation of adjuvants as a design strategy to optimize cancer vaccine efficacy, safety, and tolerability.

Assuntos

Imunoterapia; Neoplasias; Imunoterapia/métodos; Humanos; Neoplasias/imunologia; Neoplasias/terapia; Ligantes; Receptores Toll-Like/agonistas; Receptores Toll-Like/imunologia; Nanopartículas/química; Nanopartículas/uso terapêutico; Animais; Vacinas Anticâncer/imunologia; Adjuvantes Imunológicos/farmacologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoterapia / Neoplasias Limite: Animals / Humans Idioma: En Revista: Cell Rep Methods Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Canadá

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