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Elevated levels of IL-12/IL-23p40 in Nova Scotia Duck Tolling Retrievers with autoimmune disease and lymphoma.
Nilsson, Malin; Kozyrev, Sergey V; Saellström, Sara; Johansson, Siri; Andersson, Göran; Lindblad-Toh, Kerstin; Hansson-Hamlin, Helene; Rönnberg, Henrik.
Afiliação
  • Nilsson M; Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden. malin.nilsson@slu.se.
  • Kozyrev SV; Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
  • Saellström S; SciLifeLab, Uppsala University, Uppsala, Sweden.
  • Johansson S; Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
  • Andersson G; Department of Animal Biosciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
  • Lindblad-Toh K; Anicura Kalmarsund Animal Hospital, Kalmar, Sweden.
  • Hansson-Hamlin H; Department of Animal Biosciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
  • Rönnberg H; Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Sci Rep ; 14(1): 11624, 2024 05 21.
Article em En | MEDLINE | ID: mdl-38773194
ABSTRACT
The Nova Scotia Duck Tolling Retriever (NSDTR) is predisposed to immune mediated rheumatic disease (IMRD), steroid-responsive meningitis-arteritis (SRMA) and certain forms of cancer. Cytokines are the main regulators of the immune system. Interleukin 2 is a cytokine involved in activation of T regulatory cells, playing a role in central tolerance and tumor immunity. Interleukin 12 and interleukin 23 share the same subunit, p40, and are both pro-inflammatory cytokines. The aim of this study was to compare levels of IL-2 in healthy NSDTRs to those with cancer or autoimmune disease and to compare levels of IL-12/IL-23p40 in healthy NSDTRs and beagles versus NSDTRs with cancer or autoimmune disease. 62 dogs were included in the analysis of IL-12/IL-23p40; healthy NSDTRs (n = 16), healthy beagles (n = 16), NSDTRs autoimmune (n = 18) and NDSTRs lymphoma/mastocytoma (n = 12) and 68 dogs for IL-2; healthy (n = 20), autoimmune (n = 36) and lymphoma/mastocytoma/adenocarcinoma (n = 12). NSDTRs with autoimmune disease had higher levels of IL-12/IL-23p40 compared to healthy dogs (p = 0.008). NSDTRs with lymphoma also had higher levels of IL-12/IL-23p40 compared to healthy NSDTRs (p = 0.002). There was no difference in levels of IL-2 between healthy and diseased NSDTR. Statistical analysis was performed using Bonferroni corrections for multiple testing. These findings can contribute to the knowledge of autoimmune disease and cancer in dogs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Interleucina-12 / Doenças do Cão / Linfoma Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Suécia

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Interleucina-12 / Doenças do Cão / Linfoma Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Suécia