Genome-wide identification of replication fork stalling/pausing sites and the interplay between RNA Pol II transcription and DNA replication progression.

Rojas, Patricia; Wang, Jianming; Guglielmi, Giovanni; Sadurnì, Martina Mustè; Pavlou, Lucas; Leung, Geoffrey Ho Duen; Rajagopal, Vijay; Spill, Fabian; Saponaro, Marco

Rojas, Patricia; Wang, Jianming; Guglielmi, Giovanni; Sadurnì, Martina Mustè; Pavlou, Lucas; Leung, Geoffrey Ho Duen; Rajagopal, Vijay; Spill, Fabian; Saponaro, Marco.

Afiliação

Rojas P; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Wang J; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Guglielmi G; School of Mathematics, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Sadurnì MM; Department of Biomedical Engineering, University of Melbourne, Melbourne, VIC, 3010, Australia.
Pavlou L; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Leung GHD; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Rajagopal V; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Spill F; Department of Biomedical Engineering, University of Melbourne, Melbourne, VIC, 3010, Australia.
Saponaro M; School of Mathematics, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Genome Biol ; 25(1): 126, 2024 05 21.

Article em En | MEDLINE | ID: mdl-38773641

Assuntos

Replicação do DNA; RNA Polimerase II; Transcrição Gênica; RNA Polimerase II/metabolismo; Humanos; Fase S/genética; Dano ao DNA; Proteínas Mutadas de Ataxia Telangiectasia/metabolismo; Proteínas Mutadas de Ataxia Telangiectasia/genética; Genoma Humano; Origem de Replicação

Palavras-chave

DNA damage; DNA replication; RNA Pol II transcription; Replication fork pausing/stalling; Replication fork speed; Replication stress; Transcription elongation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transcrição Gênica / RNA Polimerase II / Replicação do DNA Limite: Humans Idioma: En Revista: Genome Biol Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido

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