Organophosphate pesticide exposure and risk of SARS-CoV-2 infection.
Environ Res
; 255: 119214, 2024 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-38788790
ABSTRACT
Several studies have reported immune modulation by organophosphate (OP) pesticides, but the relationship between OP exposure and SARS-CoV-2 infection is yet to be studied. We used two different measures of OP pesticide exposure (urinary biomarkers (N = 154) and residential proximity to OP applications (N = 292)) to examine the association of early-childhood and lifetime exposure to OPs and risk of infection of SARS-CoV-2 using antibody data. Our study population consisted of young adults (ages 18-21 years) from the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) Study, a longitudinal cohort of families from a California agricultural region. Urinary biomarkers reflected exposure from in utero to age 5 years. Residential proximity reflected exposures between in utero and age 16 years. SARS-CoV-2 antibodies in blood samples collected between June 2022 and January 2023 were detected via two enzyme linked immunosorbent assays, each designed to bind to different SARS-CoV-2 antigens. We performed logistic regression for each measure of pesticide exposure, adjusting for covariates from demographic data and self-reported questionnaire data. We found increased odds of SARS-CoV-2 infection among participants with higher urinary biomarkers of OPs in utero (OR = 1.94, 95% CI 0.71, 5,58) and from age 0-5 (OR = 1.90, 95% CI 0.54, 6.95).
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Praguicidas
/
Exposição Ambiental
/
SARS-CoV-2
/
COVID-19
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
/
Pregnancy
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Environ Res
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos