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Cannabidiol in the dorsal hippocampus attenuates emotional and cognitive impairments related to neuropathic pain: The role of prelimbic neocortex-hippocampal connections.
Medeiros, Ana Carolina; Medeiros, Priscila; Pigatto, Glauce Regina; Maione, Sabatino; Coimbra, Norberto Cysne; de Freitas, Renato Leonardo.
Afiliação
  • Medeiros AC; Multi-User Center of Neuroelectrophysiology, Department of Surgery and Anatomy, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, SP 14049-900, Brazil; Laboratory of Neurosciences of Pain & Emotions, Department of Surgery and Anatomy
  • Medeiros P; Multi-User Center of Neuroelectrophysiology, Department of Surgery and Anatomy, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, SP 14049-900, Brazil; Laboratory of Neurosciences of Pain & Emotions, Department of Surgery and Anatomy
  • Pigatto GR; Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, FMRP-USP, Av. Bandeirantes, 3900, Ribeirão Preto, SP 14049-900, Brazil.
  • Maione S; Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples 80138, Italy.
  • Coimbra NC; Multi-User Center of Neuroelectrophysiology, Department of Surgery and Anatomy, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, SP 14049-900, Brazil; Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, FMRP-U
  • de Freitas RL; Multi-User Center of Neuroelectrophysiology, Department of Surgery and Anatomy, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, SP 14049-900, Brazil; Laboratory of Neurosciences of Pain & Emotions, Department of Surgery and Anatomy
Article em En | MEDLINE | ID: mdl-38797491
ABSTRACT
BACKGROUND AND

PURPOSE:

Chronic neuropathic pain (NP) is commonly associated with cognitive and emotional impairments. Cannabidiol (CBD) presents a broad spectrum of action with a potential analgesic effect. This work investigates the CBD effect on comorbidity between chronic NP, depression, and memory impairment. EXPERIMENTAL

APPROACH:

The connection between the neocortex and the hippocampus was investigated with biotinylated dextran amine (BDA) deposits in the prelimbic cortex (PrL). Wistar rats were submitted to chronic constriction injury (CCI) of the sciatic nerve and CA1 treatment with CBD (15, 30, 60 nmol). KEY

RESULTS:

BDA-labeled perikarya and terminal buttons were found in CA1 and dentate gyrus. CCI-induced mechanical and cold allodynia increased c-Fos protein expression in the PrL and CA1. The number of astrocytes in PrL and CA1 increased, and the number of neuroblasts decreased in CA1. Animals submitted to CCI procedure showed increasing depressive-like behaviors, such as memory impairment. CBD (60 nmol) treatment decreased mechanical and cold allodynia, attenuated depressive-associated behaviors, and improved memory performance. Cobalt chloride (CoCl2 1 nM), WAY-100635 (0.37 nmol), and AM251 (100 nmol) intra-PrL reversed the effect of CA1 treatment with CBD (60 nmol) on nociceptive, cognitive, and depressive behaviors.

CONCLUSION:

CBD represents a promising therapeutic perspective in the pharmacological treatment of chronic NP and associated comorbidities such as depression and memory impairments. The CBD effects possibly recruit the CA1-PrL pathway, inducing neuroplasticity. CBD acute treatment into the CA1 produces functional and molecular morphological improvements.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canabidiol / Ratos Wistar / Neocórtex / Disfunção Cognitiva / Hipocampo / Neuralgia Limite: Animals Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canabidiol / Ratos Wistar / Neocórtex / Disfunção Cognitiva / Hipocampo / Neuralgia Limite: Animals Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Ano de publicação: 2024 Tipo de documento: Article