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A Case of Chronic Hepatitis B in which HBs Antigen Seroclearance was Induced by Pegpegylated-interferonα-2a after Hepatocellular Carcinoma Treatment with Nucleos(t)ide Analogues: A Five-year Follow-up.
Mimura, Shima; Ono, Masafumi; Fujita, Koji; Takuma, Kei; Nakahara, Mai; Oura, Kyoko; Tadokoro, Tomoko; Tani, Joji; Morishita, Asahiro; Kagawa, Seiko; Okano, Keiichi; Himoto, Takashi; Masaki, Tsutomu.
Afiliação
  • Mimura S; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Japan.
  • Ono M; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Japan.
  • Fujita K; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Japan.
  • Takuma K; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Japan.
  • Nakahara M; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Japan.
  • Oura K; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Japan.
  • Tadokoro T; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Japan.
  • Tani J; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Japan.
  • Morishita A; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Japan.
  • Kagawa S; Department of Pathology, Faculty of Medicine, Kagawa University, Japan.
  • Okano K; Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University, Japan.
  • Himoto T; Department of Medical Technology, Kagawa Prefectural University of Health Sciences, Japan.
  • Masaki T; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Japan.
Intern Med ; 2024 May 30.
Article em En | MEDLINE | ID: mdl-38811223
ABSTRACT
We herein report a 40-year-old Japanese man with chronic hepatitis B genotype C (viral load 6.7 LC/mL) who developed hepatocellular carcinoma (HCC) despite achieving undetectable hepatitis B virus (HBV) DNA levels with nucleos (t) ide analog (NA) treatment (entecavir). Notably, his hepatitis B surface antigen (HBsAg) level remained elevated at 388.4 IU/mL. Given the continued risk of carcinogenesis associated with HBsAg positivity, we initiated pegylated interferon (PEG-IFN) therapy one month after HCC surgery. Following three periods of PEG-IFN treatment, HBsAg seroclearance (HBsAg-negative state) was achieved.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Intern Med Assunto da revista: MEDICINA INTERNA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Intern Med Assunto da revista: MEDICINA INTERNA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão