"Sweet space" strategy for solvent system selection in countercurrent chromatography: A case study on separation of polyunsaturated fatty acids from borage oil.
J Sep Sci
; 47(11): e2400195, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38819780
ABSTRACT
This study presents a comprehensive strategy for the selection and optimization of solvent systems in countercurrent chromatography (CCC) for the effective separation of compounds. With a focus on traditional organic solvent systems, the research introduces a "sweet space" strategy that merges intuitive understanding with mathematical accuracy, addressing the significant challenges in solvent system selection, a critical bottleneck in the widespread application of CCC. By employing a combination of volume ratios and graphical representations, including both regular and trirectangular tetrahedron models, the proposed approach facilitates a more inclusive and user-friendly strategy for solvent system selection. This study demonstrates the potential of the proposed strategy through the successful separation of gamma-linolenic acid, oleic acid, and linoleic acid from borage oil, highlighting the strategy's effectiveness and practical applicability in CCC separations.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Solventes
/
Óleos de Plantas
/
Distribuição Contracorrente
Idioma:
En
Revista:
J Sep Sci
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China