Low-dose aspirin for the prevention of atherosclerotic cardiovascular disease.
Eur Heart J
; 45(27): 2362-2376, 2024 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-38839268
ABSTRACT
During the past 30â
years, several developments have occurred in the antiplatelet field, including the role of aspirin in primary prevention of atherosclerotic cardiovascular disease. There have been several attempts to develop antiplatelet drugs more effective and safer than aspirin and a shift in emphasis from efficacy to safety, advocating aspirin-free antiplatelet regimens after percutaneous coronary intervention. Evidence supporting a chemopreventive effect of low-dose aspirin against colorectal (and other digestive tract) cancer has also strengthened. The aim of this article is to revisit the role of aspirin in the prevention of atherothrombosis across the cardiovascular risk continuum, in view of developments in the antiplatelet field. The review will offer a clinical perspective on aspirin's mechanism of action, pharmacokinetics, and pharmacodynamics. This will be followed by a detailed discussion of its clinical efficacy and safety.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Inibidores da Agregação Plaquetária
/
Aspirina
/
Aterosclerose
Limite:
Humans
Idioma:
En
Revista:
Eur Heart J
/
Eur. heart j
/
European heart journal
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Itália