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Nickel-catalyzed hydrodefluorination/deuterodefluorination of CF3-alkenes with formic acid.
Yang, Peng; Yu, Haiping; Zhai, Runze; Zhou, Jianrong Steve; Tang, Bo.
Afiliação
  • Yang P; College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, P. R. China. yangpeng@sdnu.edu.cn.
  • Yu H; College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, P. R. China. yangpeng@sdnu.edu.cn.
  • Zhai R; College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, P. R. China. yangpeng@sdnu.edu.cn.
  • Zhou JS; State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
  • Tang B; College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, P. R. China. yangpeng@sdnu.edu.cn.
Chem Commun (Camb) ; 60(51): 6548-6551, 2024 Jun 20.
Article em En | MEDLINE | ID: mdl-38842110
ABSTRACT
The synthesis of deuterated gem-difluoroalkenes via selective deuterodefluorination of ß-CF3-cinnamates using a nickel catalyst has been reported for the first time. Commercially available deuterated formic acid is a cheap and convenient deuterium source. The nickel-catalyst showed high selectivity for monodefluorination and avoided competitive reactions such as multiple defluorination or hydrogenation.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2024 Tipo de documento: Article