Genetic Evidence for a Causal Link between Intra-Pancreatic Fat Deposition and Pancreatitis: a Mendelian Randomization Study.
medRxiv
; 2024 Jun 04.
Article
em En
| MEDLINE
| ID: mdl-38883800
ABSTRACT
Introduction:
Recent associative studies have linked intra-pancreatic fat deposition (IPFD) with risk of pancreatitis, but the causal relationship remains unclear.Methods:
Utilizing Mendelian randomization, we evaluated the causal association between genetically predicted IPFD and pancreatitis. This approach utilized genetic variants from genome-wide association studies of IPFD (n=25,617), acute pancreatitis (n=6,787 cases/361,641 controls), and chronic pancreatitis (n=3,875 cases/361,641 controls).Results:
Genetically predicted IPFD was significantly associated with acute pancreatitis (OR per 1-SD increase 1.40[95%CI1.12-1.76], p=0.0032) and chronic pancreatitis (OR1.64[95%CI1.13-2.39], p=0.0097).Discussion:
Our findings support a causal role of IPFD in pancreatitis, suggesting that reducing IPFD could lower the risk of pancreatitis.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
MedRxiv
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão