Development of the Cardiac Conduction System.
Adv Exp Med Biol
; 1441: 185-200, 2024.
Article
em En
| MEDLINE
| ID: mdl-38884712
ABSTRACT
The electrical impulses that coordinate the sequential, rhythmic contractions of the atria and ventricles are initiated and tightly regulated by the specialized tissues of the cardiac conduction system. In the mature heart, these impulses are generated by the pacemaker cardiomyocytes of the sinoatrial node, propagated through the atria to the atrioventricular node where they are delayed and then rapidly propagated to the atrioventricular bundle, right and left bundle branches, and finally, the peripheral ventricular conduction system. Each of these specialized components arise by complex patterning events during embryonic development. This chapter addresses the origins and transcriptional networks and signaling pathways that drive the development and maintain the function of the cardiac conduction system.
Palavras-chave
Atrioventricular bundle; Atrioventricular canal; Atrioventricular junction; Atrioventricular node; Bundle branches; Bundle of His; Cardiac conduction system; Conduction system; Pacemaker; Purkinje Fiber; Sinoatrial node; Sinus venosus; Ventricular conduction system; peripheral ventricular conduction system
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sistema de Condução Cardíaco
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Adv Exp Med Biol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Holanda