Protein restriction slows the development and progression of pathology in a mouse model of Alzheimer's disease.
Nat Commun
; 15(1): 5217, 2024 Jun 18.
Article
em En
| MEDLINE
| ID: mdl-38890307
ABSTRACT
Dietary protein is a critical regulator of metabolic health and aging. Low protein diets are associated with healthy aging in humans, and dietary protein restriction extends the lifespan and healthspan of mice. In this study, we examined the effect of protein restriction (PR) on metabolic health and the development and progression of Alzheimer's disease (AD) in the 3xTg mouse model of AD. Here, we show that PR promotes leanness and glycemic control in 3xTg mice, specifically rescuing the glucose intolerance of 3xTg females. PR induces sex-specific alterations in circulating and brain metabolites, downregulating sphingolipid subclasses in 3xTg females. PR also reduces AD pathology and mTORC1 activity, increases autophagy, and improves the cognition of 3xTg mice. Finally, PR improves the survival of 3xTg mice. Our results suggest that PR or pharmaceutical interventions that mimic the effects of this diet may hold promise as a treatment for AD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Camundongos Transgênicos
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Progressão da Doença
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Dieta com Restrição de Proteínas
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Modelos Animais de Doenças
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Doença de Alzheimer
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Nat Commun
Assunto da revista:
BIOLOGIA
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CIENCIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos