Endopeptidase activities of Clostridium botulinum toxins in the development of this bacterium.
Res Microbiol
; 175(7): 104216, 2024.
Article
em En
| MEDLINE
| ID: mdl-38897423
ABSTRACT
By-products like CO2 and organic acids, produced during Clostridium botulinum growth, appear to inhibit its development and reduce ATP production. A decrease in ATP production creates an imbalance in the ATP/GTP ratio. GTP activates CodY, which regulates BoNT expression. This toxin is released into the extracellular medium. Its light chains act as a specific endopeptidase, targeting SNARE proteins. The specific amino acids released enter the cells and are metabolized by the Stickland reaction, resulting in the synthesis of ATP. This ATP might then be used by histidine kinases to activate Spo0A, the main regulator initiating sporulation, through phosphorylation.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Endopeptidases
/
Toxinas Botulínicas
/
Clostridium botulinum
Idioma:
En
Revista:
Res Microbiol
Assunto da revista:
MICROBIOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article