A solvent controlled regioselective synthesis of 2- and 4-substituted α-carbolines under palladium catalysis.
Chem Commun (Camb)
; 60(58): 7427-7430, 2024 Jul 16.
Article
em En
| MEDLINE
| ID: mdl-38904121
ABSTRACT
A facile method for the chemodivergent synthesis of α-carbolines 1via palladium catalyzed [3+3] annulations of tosyliminoindolines 6 with α, ß-unsaturated aldehydes 7 is described. Mechanistically, this cascade reaction proceeds through either a carba-Michael (in DMF) or aza-Michael (in NMA) pathway followed by intramolecular cyclization of the intermediate. A preliminary photo-physical study on selected products is also reported.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Índia