Cordyceps militaris: A novel mushroom platform for metabolic engineering.
Biotechnol Adv
; 74: 108396, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38906495
ABSTRACT
Cordyceps militaris, widely recognized as a medicinal and edible mushroom in East Asia, contains a variety of bioactive compounds, including cordycepin (COR), pentostatin (PTN) and other high-value compounds. This review explores the potential of developing C. militaris as a cell factory for the production of high-value chemicals and nutrients. This review comprehensively summarizes the fermentation advantages, metabolic networks, expression elements, and genome editing tools specific to C. militaris and discusses the challenges and barriers to further research on C. militaris across various fields, including computational biology, existing DNA elements, and genome editing approaches. This review aims to describe specific and promising opportunities for the in-depth study and development of C. militaris as a new chassis cell. Additionally, to increase the practicability of this review, examples of the construction of cell factories are provided, and promising strategies for synthetic biology development are illustrated.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cordyceps
/
Engenharia Metabólica
Idioma:
En
Revista:
Biotechnol Adv
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China