Unveiling the role of chronic inflammation in ovarian aging: insights into mechanisms and clinical implications.
Hum Reprod
; 39(8): 1599-1607, 2024 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-38906835
ABSTRACT
Ovarian aging, a natural process in women and various other female mammals as they age, is characterized by a decline in ovarian function and fertility due to a reduction in oocyte reserve and quality. This phenomenon is believed to result from a combination of genetic, hormonal, and environmental factors. While these factors collectively contribute to the shaping of ovarian aging, the substantial impact and intricate interplay of chronic inflammation in this process have been somewhat overlooked in discussions. Chronic inflammation, a prolonged and sustained inflammatory response persisting over an extended period, can exert detrimental effects on tissues and organs. This review delves into the novel hallmark of aging-chronic inflammation-to further emphasize the primary characteristics of ovarian aging. It endeavors to explore not only the clinical symptoms but also the underlying mechanisms associated with this complex process. By shining a spotlight on chronic inflammation, the aim is to broaden our understanding of the multifaceted aspects of ovarian aging and its potential clinical implications.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ovário
/
Envelhecimento
/
Inflamação
Limite:
Animals
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Female
/
Humans
Idioma:
En
Revista:
Hum Reprod
Assunto da revista:
MEDICINA REPRODUTIVA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China