MicroRNA for Prediction of Teratoma and Viable Germ Cell Tumor after Chemotherapy.

Baky, Fady J; Matulewicz, Richard S; Feldman, Darren R; Hamilton, Robert J; Bagrodia, Aditya

Baky, Fady J; Matulewicz, Richard S; Feldman, Darren R; Hamilton, Robert J; Bagrodia, Aditya.

Afiliação

Baky FJ; Department of Urology, Memorial Sloan Kettering Cancer Center, 430 East 67th Street, New York, NY 10065, USA.
Matulewicz RS; Department of Urology, Memorial Sloan Kettering Cancer Center, 430 East 67th Street, New York, NY 10065, USA.
Feldman DR; Germ Cell Cancer, Department of Medicine, Memorial Sloan Kettering Cancer Center, 430 East 67th Street, New York, NY 10065, USA.
Hamilton RJ; Division of Urology, Princess Margaret Hospital, 3-130, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada.
Bagrodia A; Department of Urology, UC San Diego Health, 9400 Campus Point Drive, Suite 1-200, La Jolla, CA 92037, USA. Electronic address: bagrodia@health.ucsd.edu.

Urol Clin North Am ; 51(3): 387-394, 2024 Aug.

Article em En | MEDLINE | ID: mdl-38925741

ABSTRACT

ABSTRACT

MicroRNAs (miRNAs) are emerging as highly sensitive and specific markers for testicular germ cell tumors (GCTs) across the spectrum of disease. However, their utility in specific clinical scenarios requires further study. Here, we review the current evidence for miRNAs as tumor markers for the evaluation of treatment response in patients undergoing chemotherapy for the treatment of advanced testicular GCT.

Assuntos

Biomarcadores Tumorais; MicroRNAs; Neoplasias Embrionárias de Células Germinativas; Teratoma; Neoplasias Testiculares; Humanos; Neoplasias Testiculares/tratamento farmacológico; Neoplasias Testiculares/genética; Neoplasias Testiculares/patologia; Masculino; MicroRNAs/genética; Neoplasias Embrionárias de Células Germinativas/tratamento farmacológico; Neoplasias Embrionárias de Células Germinativas/genética; Neoplasias Embrionárias de Células Germinativas/patologia; Teratoma/tratamento farmacológico; Teratoma/genética; Teratoma/patologia; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/análise

Palavras-chave

Cisplatin-resistance; Germ cell tumors; Retroperitoneal lymph node dissection (RPLND); Testicular cancer; Tumor markers; miRNA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Teratoma / Neoplasias Testiculares / Biomarcadores Tumorais / Neoplasias Embrionárias de Células Germinativas / MicroRNAs Limite: Humans / Male Idioma: En Revista: Urol Clin North Am Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

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