A key regulator of male gametogenesis in Cryptosporidium.

Lander, Noelia; Chiurillo, Miguel A

Lander, Noelia; Chiurillo, Miguel A.

Afiliação

Lander N; Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221-006, USA. Electronic address: landernm@ucmail.uc.edu.
Chiurillo MA; Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221-006, USA.

Trends Parasitol ; 40(8): 662-663, 2024 Aug.

Article em En | MEDLINE | ID: mdl-38944561

ABSTRACT

ABSTRACT

Gamete development is a precisely programmed process in Cryptosporidium parvum, a leading cause of diarrheal disease worldwide. Nava et al. recently described the developmentally regulated expression of CDPK5 during male gametogenesis. Here we discuss their main findings, posing this protein kinase as a promising target for antiparasitic interventions.

Assuntos

Cryptosporidium parvum; Gametogênese; Masculino; Cryptosporidium parvum/genética; Cryptosporidium parvum/fisiologia; Proteínas de Protozoários/metabolismo; Proteínas de Protozoários/genética; Animais; Humanos; Criptosporidiose/parasitologia

Palavras-chave

CDPK5; apicomplexa; calcium signaling; cell differentiation; drug target validation; gamete development

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cryptosporidium parvum / Gametogênese Limite: Animals / Humans / Male Idioma: En Revista: Trends Parasitol Assunto da revista: PARASITOLOGIA Ano de publicação: 2024 Tipo de documento: Article

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