Effect of Acupuncture on Neurogenic Claudication Among Patients With Degenerative Lumbar Spinal Stenosis : A Randomized Clinical Trial.
Ann Intern Med
; 177(8): 1048-1057, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38950397
ABSTRACT
BACKGROUND:
Acupuncture may improve degenerative lumbar spinal stenosis (DLSS), but evidence is insufficient.OBJECTIVE:
To investigate the effect of acupuncture for DLSS.DESIGN:
Multicenter randomized clinical trial. (ClinicalTrials.gov NCT03784729).SETTING:
5 hospitals in China.PARTICIPANTS:
Patients with DLSS and predominantly neurogenic claudication pain symptoms. INTERVENTION 18 sessions of acupuncture or sham acupuncture (SA) over 6 weeks, with 24-week follow-up after treatment. MEASUREMENTS The primary outcome was change from baseline in the modified Roland-Morris Disability Questionnaire ([RMDQ] score range, 0 to 24; minimal clinically important difference [MCID], 2 to 3). Secondary outcomes were the proportion of participants achieving minimal (30% reduction from baseline) and substantial (50% reduction from baseline) clinically meaningful improvement per the modified RMDQ.RESULTS:
A total of 196 participants (98 in each group) were enrolled. The mean modified RMDQ score was 12.6 (95% CI, 11.8 to 13.4) in the acupuncture group and 12.7 (CI, 12.0 to 13.3) in the SA group at baseline, and decreased to 8.1 (CI, 7.1 to 9.1) and 9.5 (CI, 8.6 to 10.4) at 6 weeks, with an adjusted difference in mean change of -1.3 (CI, -2.6 to -0.03; P = 0.044), indicating a 43.3% greater improvement compared with SA. The between-group difference in the proportion of participants achieving minimal and substantial clinically meaningful improvement was 16.0% (CI, 1.6% to 30.4%) and 12.6% (CI, -1.0% to 26.2%) at 6 weeks. Three cases of treatment-related adverse events were reported in the acupuncture group, and 3 were reported in the SA group. All events were mild and transient.LIMITATION:
The SA could produce physiologic effects.CONCLUSION:
Acupuncture may relieve pain-specific disability among patients with DLSS and predominantly neurogenic claudication pain symptoms, although the difference with SA did not reach MCID. The effects may last 24 weeks after 6-week treatment. PRIMARY FUNDING SOURCE 2019 National Administration of Traditional Chinese Medicine "Project of building evidence-based practice capacity for TCM-Project BEBPC-TCM" (NO. 2019XZZX-ZJ).
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Estenose Espinal
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Terapia por Acupuntura
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Claudicação Intermitente
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Vértebras Lombares
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ann Intern Med
Ano de publicação:
2024
Tipo de documento:
Article