Sensing the squeeze: nuclear mechanotransduction in health and disease.
Nucleus
; 15(1): 2374854, 2024 Dec.
Article
em En
| MEDLINE
| ID: mdl-38951951
ABSTRACT
The nucleus not only is a repository for DNA but also a center of cellular and nuclear mechanotransduction. From nuclear deformation to the interplay between mechanosensing components and genetic control, the nucleus is poised at the nexus of mechanical forces and cellular function. Understanding the stresses acting on the nucleus, its mechanical properties, and their effects on gene expression is therefore crucial to appreciate its mechanosensitive function. In this review, we examine many elements of nuclear mechanotransduction, and discuss the repercussions on the health of cells and states of illness. By describing the processes that underlie nuclear mechanosensation and analyzing its effects on gene regulation, the review endeavors to open new avenues for studying nuclear mechanics in physiology and diseases.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Núcleo Celular
/
Mecanotransdução Celular
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nucleus
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Canadá