Autoimmunity in patients with inborn errors of immunity: A case series.
Reumatol Clin (Engl Ed)
; 20(7): 398-400, 2024.
Article
em En
| MEDLINE
| ID: mdl-38971706
ABSTRACT
OBJECTIVE:
To assess the prevalence of systemic and organ-specific autoimmunity among individuals with human inborn errors of immunity (IEI).METHODS:
Retrospective study. We recorded demographic variables, type of immunodeficiency, and systemic and organ specific autoimmunity.RESULTS:
We included 48 patients (54.1% men) with mean age of 32.1 years. The most common IEIs included combined immunodeficiency with syndromic features (31.2%) and predominantly antibody deficiency (20.1%). We observed autoimmunity in 15 patients (31.2%) 12 organ-specific autoimmunity and 5 systemic autoimmunity, not mutually exclusive groups. Organ-specific autoimmunity preceded the onset of IEI in 5 patients, was concurrent in one patient, and developed after the diagnosis of IEI in 6 cases. From the systemic autoimmunity group, we observed polyarteritis nodosa (nâ¯=â¯2), antiphospholipid syndrome (APS) (nâ¯=â¯2), and overlap of limited systemic sclerosis/APS/Sjögren's syndrome (nâ¯=â¯1), and in all cases, this occurred after the IEI diagnosis.CONCLUSION:
Our findings confirm the coexistence of autoimmunity and IEI. This overlap may be attributed to B and T cell disorders, as well as potential alterations in the microbiota in these patients.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
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Autoimunidade
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Middle aged
Idioma:
En
Revista:
Reumatol Clin (Engl Ed)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
México