Association of dysphagia severity in multiple system atrophy with the specific binding ratio on dopamine transporter SPECT.
J Neurol Sci
; 463: 123116, 2024 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-38981418
ABSTRACT
OBJECTIVE:
Dysphagia in multiple system atrophy (MSA) is life-threatening and is caused by parkinsonism with cerebellar ataxia as a contributing factor. The present study investigated the relationship between dysphagia severity in MSA and the specific binding ratio (SBR) on dopamine transporter (DaT) SPECT using the Hyodo score, a qualitative scale for use with fiberoptic endoscopic evaluation of swallowing (FEES).METHODS:
Hyodo score's ability to predict aspiration during a FEES examination of 88 patients with MSA was first tested. Then the clinical characteristics, Hyodo score, and SBR of patients with either predominant parkinsonism (MSA-P; n = 11) or cerebellar ataxia (MSA-C; n = 25) who underwent FEES and DaT SPECT simultaneously were compared.RESULTS:
Logistic regression demonstrated that the Hyodo score was a significant predictive factor of aspiration (p = 0.003). The MSA-P group had a significantly higher Hyodo score (p = 0.026) and lower SBR (p = 0.011) than the MSA-C group while neither group demonstrated any significant difference in disease duration at the FEES examination. Linear regression demonstrated a significant, inverse correlation between the Hyodo score and SBR in the MSA-P (p = 0.044; r = -0.616) and MSA-C (p = 0.044; r = -0.406) groups. When the effect of SBR was removed by analysis of covariance, no significant difference in the Hyodo score remained between the groups.CONCLUSIONS:
Our results suggested an association between presynaptic changes in nigrostriatal dopaminergic neurons and dysphagia severity in MSA which largely contributes to the difference in dysphagia severity between MSA-P and MSA-C.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Índice de Gravidade de Doença
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Transtornos de Deglutição
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Tomografia Computadorizada de Emissão de Fóton Único
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Atrofia de Múltiplos Sistemas
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Proteínas da Membrana Plasmática de Transporte de Dopamina
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Neurol Sci
Ano de publicação:
2024
Tipo de documento:
Article