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Neutropenia Induced by Ceftriaxone and Meropenem.
Aung, Zay Yar; Elmagraby, Khaled; Nica, Alexandra.
Afiliação
  • Aung ZY; Acute Medicine Department, Northampton General Hospital, NHS Trust, Northampton, UK.
  • Elmagraby K; Acute Medicine Department, Northampton General Hospital, NHS Trust, Northampton, UK.
  • Nica A; Acute Medicine Department, Northampton General Hospital, NHS Trust, Northampton, UK.
Eur J Case Rep Intern Med ; 11(7): 004593, 2024.
Article em En | MEDLINE | ID: mdl-38984172
ABSTRACT
Neutropenia by non-chemotherapy drugs is an extremely rare idiosyncratic life-threatening drug reaction. Ceftriaxone and meropenem are widely used broad-spectrum antibiotics and are generally safe and well tolerated. The authors present a case of neutropenia induced by ceftriaxone and meropenem in an adult patient. The resolution of neutropenia occurred within 48 hours of ceftriaxone and meropenem being discontinued. Although antibiotic-induced neutropenia is uncommon, clinicians should be mindful of this adverse drug effect because of its potential development of severe neutropenia, septicaemia, septic shock, deep-seated infections and even death. Therefore, neutropenic sepsis treatment should be initiated without delay, particularly if the patient becomes septic and febrile. Granulocyte-colony stimulation factor (G-CSF) may be administered to facilitate the recovery process with daily monitoring of neutrophil count. Mortalities from antibiotic-induced neutropenia remain rare, with a range of 2.5-5%. LEARNING POINTS Beta-lactam antibiotics and cabapenem are widely prescribed antibiotics for the treatment of various infections, but they can uncommonly cause neutropenia as adverse effects.Severe neutropenia may lead to severe life-threatening sepsis, shock and even death.Drug-induced neutropenia typically improves with the cessation of offending agents, supportive treatment and granulocyte-colony stimulating factor (G-CSF) which may shorten the recovery time.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Eur J Case Rep Intern Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Eur J Case Rep Intern Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido