Effect of various contraceptives on oocyte yield and maturation in patients undergoing planned oocyte cryopreservation.
Reprod Biomed Online
; 49(3): 104105, 2024 09.
Article
em En
| MEDLINE
| ID: mdl-38986195
ABSTRACT
RESEARCH QUESTION Do the various forms of hormonal and non-hormonal contraceptives have any association with ovarian stimulation outcomes, such as oocyte yield and maturation, in patients undergoing planned oocyte cryopreservation (POC)? DESIGN:
This retrospective cohort study included all patients who underwent POC cycles between 2011 and 2023. The use of types of contraception before a POC cycle was recorded. The study evaluated the median number of cumulus-oocyte complexes obtained after vaginal oocyte retrieval and the proportion of metaphase II oocytes that underwent vitrification among all the cohorts.RESULTS:
A total of 4059 oocyte freezing cycles were included in the analysis. Eight types of contraceptive method were recognized in patients undergoing ovarian stimulation intrauterine device (IUD), copper (nâ¯=â¯84); IUD, levonorgestrel low dose (<52 mg) (nâ¯=â¯37); IUD, levonorgestrel (nâ¯=â¯192); subdermal etonogestrel implant (nâ¯=â¯14); injectable medroxyprogesterone acetate (nâ¯=â¯11); etonogestrel vaginal ring (nâ¯=â¯142); combined oral contraceptive pills (nâ¯=â¯2349); and norelgestromin transdermal patch (nâ¯=â¯10). The control group included patients not using contraceptives or using barrier or calendar methods (nâ¯=â¯1220). Among all the cohorts the median number of cumulus-oocyte complexes retrieved during oocyte retrieval was comparable (Pâ¯=â¯0.054), and a significant difference in oocyte maturity rate with median number of vitrified oocytes was found (Pâ¯=â¯0.03, P < 0.001, respectively). After adjusting for confounders a multivariate analysis found no association between the type of contraceptive and proportion of metaphase II oocytes available for cryopreservation.CONCLUSIONS:
Among the various forms of contraception, none was shown to have an adverse association with oocyte yield or maturation rate in patients undergoing POC.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oócitos
/
Criopreservação
/
Recuperação de Oócitos
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Reprod Biomed Online
Assunto da revista:
MEDICINA REPRODUTIVA
Ano de publicação:
2024
Tipo de documento:
Article