2D electrical admittance lattice model of biological cellular system for modeling electroporation.
Biophys J
; 123(18): 3176-3187, 2024 Sep 17.
Article
em En
| MEDLINE
| ID: mdl-39014896
ABSTRACT
In this work, a new modeling approach is presented to obtain a two-dimensional transport lattice of a biological cellular system for the calculation of the potential distribution throughout the system and investigation of the corresponding membrane electroporation. The presented model has been obtained by a modified bilayer model of the cell membrane. This modified membrane model allows for an effective inclusion of the shape of the cell membrane in the potential calculation. The results of the model have shown good agreement with the results of the well-known Schwan equation and COMSOL Multiphysics for the circular cell. The simulation results show that both membranes of a mitochondrion can be simultaneously electroporated by an alternating voltage source with frequencies between 1 MHz and 1 GHz.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Membrana Celular
/
Eletroporação
/
Modelos Biológicos
Idioma:
En
Revista:
Biophys J
Ano de publicação:
2024
Tipo de documento:
Article