Accuracy of salivary biomarkers in the diagnosis of periodontal status and coronary heart disease.
J Med Life
; 17(4): 442-448, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-39071510
ABSTRACT
Inflammatory illnesses, such as periodontitis and atherosclerotic coronary heart disease (ASCHD), trigger the production of pro-inflammatory mediators. The aim of this study was to assess the accuracy of using salivary interleukin-1ß (IL-1ß), interleukin-18 (IL-18), and gasdermin D (GSDMD) in discerning patients with periodontitis with and without ASCHD from healthy individuals, and to assess their correlation with clinical periodontal parameters and low-density lipoprotein (LDL) levels. The study involved 120 participants:
30 were healthy subjects (control group, C), 30 had generalized periodontitis (group P), 30 had ASCHD and clinically healthy periodontium (group AS-C), and 30 had ASCHD and generalized periodontitis (group AS-P). Saliva and blood samples were collected, and periodontal characteristics such as plaque index, bleeding on probing, probing pocket depth, and clinical attachment loss were examined. IL-1ß, IL-18, and GSDMD levels from saliva were determined using ELISA. LDL levels were determined from the blood samples. Groups P, AS-C, and AS-P had higher levels of salivary IL-1ß, IL-18, and GSDMD than group C. The receiver operating characteristic (ROC) curves of all biomarkers showed high diagnostic accuracy, with a significant positive correlation with the clinical parameters and LDL levels. The observed correlations between the studied pro-inflammatory mediators and disease severity suggest that these biomarkers could serve as indicators of disease progression in conditions such as periodontitis and ASCHD.Palavras-chave
AUC, area under the curve; CAL, clinical attachment level; CHD, coronary heart disease; CT, computed tomography; HDL, high-density lipoprotein; ICC, intraclass correlation coefficient; IL-18; IL-1ß; LDL, low-density lipoprotein; PLI, plaque index; PPD, pocket probing depth; TC, total cholesterol; TG, triglyceride; atherosclerotic coronary heart disease; gasdermin D; periodontitis
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Saliva
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Biomarcadores
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Doença das Coronárias
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Interleucina-18
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Interleucina-1beta
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Med Life
Assunto da revista:
MEDICINA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Iraque