Chemo-enzymatic total synthesis: current approaches toward the integration of chemical and enzymatic transformations.
Beilstein J Org Chem
; 20: 1693-1712, 2024.
Article
em En
| MEDLINE
| ID: mdl-39076288
ABSTRACT
A steadily increasing number of reports have been published on chemo-enzymatic synthesis methods that integrate biosynthetic enzymatic transformations with chemical conversions. This review focuses on the total synthesis of natural products and classifies the enzymatic reactions into three categories. The total synthesis of five natural products cotylenol, trichodimerol, chalcomoracin, tylactone, and saframycin A, as well as their analogs, is outlined with an emphasis on comparing these chemo-enzymatic syntheses with the corresponding natural biosynthetic pathways.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Beilstein J Org Chem
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão